Using Supplements To Boost Testosterone

EARLY WARNING SIGNS OF LOW T

After the age of 30, testosterone levels begin to drop about 1% to 3% each year.* That’s a 10% to 30% drop in ten years. Among men in midlife—those over 45—at least one-third experience testosterone insufficiency.** If you’re feeling depleted, it’s helpful to know the signs of low Testosterone:

• Low energy
• Insomnia
• Loss of muscle mass
• Lower bone density
• Joint pain
• Weight gain
• Decreased sexual performance
• Irritability or anxiety
• Brain fog.

Checking Testosterone is easily done with a blood test.

WHY IT MATTERS

If low T turns out to be an issue, you’ll want to bring your levels back into balance. Your hormones protect you, and when those levels drop, the risk of more drastic conditions increases:

• Clogged blood vessels
• Diabetes
• Cardiovascular disease
• Osteoporosis
• Premature dementia

Most men are surprised to learn that Testosterone is protective against every one of these potentially fatal disorders, including diabetes, heart disease, cancer, and dementia.

SUPPORTING TESTOSTERONE WITH BOTANICALS AND MINERALS

Today, we can also increase Testosterone with oral supplements because we have more research available than we did 15 years ago. This approach is termed evidence-based medicine, because we can use the research to guide us.

Here, we’ll provide the research used to formulate the testosterone-booster, SupporT.

SupporT is a testosterone-boosting supplement formulated by Dr. Judson Brandeis, a board-certified urologist, surgeon, and principal investigator for five clinical trials on men’s health. This supplement contains ingredients confirmed in the research to help promote Testosterone and sexual function.

• DHEA Dehydroepiandrosterone is a hormone produced by the adrenal glands that our bodies convert into Testosterone, estrogen, and cortisol. Unfortunately, like Testosterone, DHEA levels start to decrease at about 30. DHEA is available in supplement form and has been studied for the potential to increase testosterone levels, particularly in individuals with low baseline levels. Replenishing DHEA has the potential to support healthier testosterone levels and has been shown to boost total Testosterone levels by 14% in men presenting with low Testosterone.
• DIM is derived from cruciferous vegetables like broccoli and cauliflower. Since DHEA is a precursor to both Testosterone and estrogen, the DIM is included in this formula to reduce conversion to estrogen, supporting higher Testosterone levels. Of note, DIM has also been found to reduce the risk of prostate cancer.

• Indian ginseng (Ashwagandha) is a plant-based botanical used worldwide in supplements and herbal remedies. This adaptogenic herb has been studied for its potential to reduce stress and improve hormone balance, including testosterone levels. Studies show that ashwagandha (“like a horse”) can help boost Testosterone, enhance muscle development, and reduce body fat.
  

• Tongkat Ali, also known as Eurycoma longifolia, is a plant native to Southeast Asia and has been traditionally used for various purposes, including as an herbal remedy for boosting testosterone levels. Some studies suggest that Tongkat Ali may have a potential impact on testosterone levels. In a study published in the Journal of the International Society of Sports Nutrition in 2013, researchers gave Tongkat Ali extract to male subjects for four weeks. They reported an increase in testosterone levels in the group that received the Tongkat Ali extract compared to the placebo group. Another study published in the Journal of Ethnopharmacology in 2014 found that Tongkat Ali supplementation significantly increased testosterone levels in men with low Testosterone. This study suggested that Tongkat Ali might have potential as a natural remedy for addressing testosterone deficiency.

• Magnesium and Zinc are minerals essential for health that are often lower in today’s typical diet. Magnesium plays a vital role in muscle function, and Zinc, a trace mineral, is crucial to cell function. Insufficient amounts of either of these elements can reduce testosterone levels in men. Ensuring an adequate intake of these minerals through diet or supplements has been found to support healthy testosterone levels, particularly in individuals with mineral deficiencies.

These nutrients and botanicals are designed to improve your overall wellbeing, while maximizing support for healthy levels of Testosterone.

LOOKING AT THE RESEARCH OF WHAT WORKS AND DOES NOT WORK TO BOOST TESTOSTERONE LEVELS IN MEN

DHEA

Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal glands that is broken down to make sex hormones, including Testosterone. Several studies have explored the relationship between DHEA supplementation and testosterone levels with key findings:

1. Dehydroepiandrosterone Supplementation and Hormonal Responses to Resistance Exercise (Journal of Applied Physiology, 2006):

This study investigated the effects of DHEA supplementation on hormonal responses to resistance exercise in young men. The results showed that DHEA supplementation led to a significant increase in serum testosterone levels compared to a placebo group.

2. Dehydroepiandrosterone Supplementation and Cognitive Functioning in Older Adults (Journal of the American Geriatrics Society, 2003):

In this study, DHEA supplementation in older adults was evaluated for its effects on cognitive function. While the primary outcomes were related to cognitive function, the study reported an increase in serum testosterone levels in the DHEA group.

It’s important to note that the effects of DHEA supplementation on testosterone levels can vary among individuals, and that the responses may be influenced by factors such as age, sex, and underlying health conditions.

DHEA supplementation is generally considered safe when used at appropriate dosages, but it may have potential interactions with medications. Therefore, it’s crucial to consult with a healthcare provider before considering DHEA supplementation, especially if you have a specific health condition that may be affected by hormonal changes.

DIM

Diindolylmethane (DIM) is often studied for its potential to support hormone balance, particularly by promoting the conversion of estrogen into its less potent forms and by reducing the conversion of Testosterone into estrogen. Studies and findings related to DIM’s ability to inhibit the conversion of Testosterone into estrogen:

1. Diindolylmethane Inhibits Estrogen-Induced Expression of Fibulin-1C and Other Genes in Human Endometrial Cells (Endocrinology, 2008):

This study investigated the effects of DIM on estrogen-induced gene expression in human endometrial cells. DIM was found to inhibit estrogen-induced gene expression, including the inhibition of the estrogen receptor (ER)-mediated pathway. This suggests that DIM may help reduce the effects of estrogen, including the conversion of Testosterone to estrogen.

Indian Ginseng (Ashwagandha)

Ashwagandha (Withania somnifera) is an adaptogenic herb traditionally used in Ayurvedic medicine, that has gained attention for its potential to influence hormonal health. There have been several studies exploring the effects of ashwagandha on testosterone levels:

1. Efficacy of Withania somnifera on Semen Quality in Male Infertility: A Randomized, Double-Blind, Placebo-Controlled Study (Phytomedicine, 2013):

This study investigated the effects of ashwagandha supplementation on semen quality and hormonal parameters in men with infertility. While the primary focus was on semen quality, the study reported that ashwagandha supplementation led to a significant increase in serum testosterone levels.

2. Examining the Effect of Withania somnifera Supplementation on Muscle Strength and Recovery: A Randomized Controlled Trial (Journal of the International Society of Sports Nutrition, 2015):

The impact of ashwagandha supplementation on muscle strength and recovery was evaluated in this clinical trial involving healthy males. Researchers reported that participants in the ashwagandha group experienced a significant increase in serum testosterone levels compared to the placebo group.

3. Efficacy of Ashwagandha (Withania somnifera ) in Improving Cardiovascular Health Risk in Prediabetes: A Randomized Double-Blind Placebo-Controlled Study (Journal of Alternative and Complementary Medicine, 2017):

This study focused on the effects of ashwagandha on cardiovascular health risk factors in individuals with prediabetes. While the primary outcomes were related to cardiovascular health, the study also reported a significant increase in serum testosterone levels in the ashwagandha group compared to the placebo group.

4. Withania somnifera Improves Semen Quality by Regulating Reproductive Hormone Levels and Oxidative Stress in Seminal Plasma of Infertile Males (Fertility and Sterility, 2010):

Researchers assessed the effects of ashwagandha supplementation on semen quality and hormonal parameters in infertile men. The findings indicated that ashwagandha supplementation led to a significant increase in serum testosterone levels.

Malaysian Ginseng (Tongkat Ali)

Malaysian Ginseng (Eurycoma longifolia or Tongkat Ali) is a medicinal plant traditionally used in Southeast Asia for its potential aphrodisiac and testosterone-boosting properties. Tongkat Ali has been studied for its potential to influence free testosterone levels in the body. Free Testosterone refers to Testosterone that is not bound to sex hormone-binding globulin (SHBG) or albumin, making it bioavailable for use by tissues in the body. Key studies on Tongkat Ali and its effects on free testosterone levels include:

1. Effect of Tongkat Ali on Stress Hormones and Psychological Mood State in Moderately Stressed Subjects (Journal of the International Society of Sports Nutrition, 2013):

This study investigated the effects of Tongkat Ali supplementation on stress hormones and mood in moderately stressed individuals. While the primary focus was on stress and mood, the study reported that Tongkat Ali supplementation was associated with a significant increase in serum testosterone levels.

2. Eurycoma longifolia as a Potential Adaptogen of Male Sexual Health: A Systematic Review on Clinical Studies (Chinese Journal of Natural Medicines, 2017):

This systematic review analyzed clinical studies on Eurycoma longifolia (Tongkat Ali) and its effects on male sexual health. Several studies reported increases in testosterone levels with Tongkat Ali supplementation, along with improvements in sexual function.

3. Effect of Tongkat Ali on Testosterone and Continuous Exercise (Medical Journal of Indonesia, 2017):

This study investigated the effects of Tongkat Ali supplementation on testosterone levels in men who engaged in continuous exercise. The results showed that Tongkat Ali supplementation led to a significant increase in serum testosterone levels compared to the control group.

4. Effect of Tongkat Ali on Free Testosterone and Muscle Mass in Men with Late-Onset Hypogonadism (The Aging Male, 2013):

This randomized, double-blind, placebo-controlled study investigated the effects of Tongkat Ali supplementation on men with late-onset hypogonadism (low testosterone levels). The study reported that Tongkat Ali supplementation resulted in a significant increase in free testosterone levels compared to the placebo group.

5. Eurycoma longifolia as a Potential Adaptogen of Male Sexual Health: A Systematic Review on Clinical Studies (Chinese Journal of Natural Medicines, 2017):

A systematic review analyzed clinical studies on Tongkat Ali and its effects on male sexual health. Several studies reported increases in free testosterone levels with Tongkat Ali supplementation, along with improvements in sexual function.

6. Tongkat Ali (Eurycoma longifolia) in Managing Inadequate Testosterone Levels in Men (International Journal of Andrology, 2005):

This study investigated the effects of Tongkat Ali on men with inadequate testosterone levels. Tongkat Ali supplementation was found to significantly increase free testosterone levels and improve various aspects of male sexual health.

Magnesium

Magnesium is an essential mineral that supports exercise performance, quality sleep, stable blood sugar, good bone health, lower blood pressure, and influence hormone regulation. Several studies have explored the relationship between magnesium and testosterone levels with key findings.

1. Effects of Magnesium Supplementation on Testosterone Levels of Athletes and Sedentary Subjects at Rest and after Exhaustion (Clinical Biochemistry, 2011):

This study investigated the effects of magnesium supplementation on testosterone levels was evaluated in athletes and sedentary participants. The results showed that magnesium supplementation led to an increase in testosterone levels, particularly in athletes after exercise.

2. The Effect of Magnesium Supplementation on Serum Testosterone Levels in Male Elite Basketball Players (Journal of Exercise Physiology Online, 2014):

Research on the impact of magnesium supplementation on serum testosterone levels found that magnesium supplementation led to a significant increase in total testosterone levels.

3. Oral Magnesium Supplementation Reduces Insulin Resistance in Non-Diabetic Subjects – A Double-Blind, Placebo-Controlled, Randomized Trial (Diabetic Medicine, 2011):

While this study primarily focused on insulin resistance, it also reported an increase in total testosterone levels in non-diabetic subjects who received magnesium supplementation.

4. Effects of Magnesium Supplementation on Testosterone Levels of Infertile Men (Biology of Trace Element Research, 2011):

The effects of magnesium supplementation on Testosterone were evaluated in this study of infertile men. The results showed that magnesium supplementation led to an increase in serum testosterone levels in the study group.

It’s important to note that while these studies suggest a positive relationship between magnesium supplementation and testosterone levels, individual responses to magnesium supplementation can vary. Note that the effects may be more pronounced in individuals with suboptimal magnesium levels.

Zinc

Zinc is an essential mineral that plays a crucial role in bodily functions, including hormone production. A number of studies have explored the relationship between Zinc and Testosterone.

1. Effect of Zinc Supplementation on Serum Testosterone Level in Adult Male Mice (Andrologia, 2016):

An animal study investigated the impact of zinc supplementation on testosterone levels in male mice. The results indicated that zinc supplementation led to a significant increase in serum testosterone levels.

2. Effects of Zinc Magnesium Aspartate (ZMA) Supplementation on Training Adaptations and Markers of Anabolism and Catabolism (Journal of the International Society of Sports Nutrition, 2004):

Testosterone levels in athletes were evaluated for the effects of ZMA, a combination of Zinc, magnesium, and vitamin B6, on testosterone levels in athletes. The findings suggested that ZMA supplementation led to a significant increase in testosterone levels in trained athletes.

3. Zinc Status and Serum Testosterone Levels of Healthy Adults (Nutrition, 1996):

This study investigated the relationship between zinc status and testosterone levels in healthy adults. The results showed that zinc-deficient individuals had lower testosterone levels compared to those with adequate zinc status.

4. Zinc Supplementation and Testosterone Concentrations in Male Elite Athletes During a 4-Week Training Camp (Journal of the International Society of Sports Nutrition, 2018):

The impact of zinc supplementation on testosterone levels was evaluated in male athletes. The results indicated that zinc supplementation was associated with a measurable increase in testosterone concentrations in just 4 weeks.

5. Effect of Zinc Supplementation on Testosterone Levels in Men with Hypogonadism (The World Journal of Men’s Health, 2019):

This clinical trial investigated the effects of zinc supplementation in men with hypogonadism (a condition characterized by low testosterone levels). The study found that zinc supplementation led to a significant increase in testosterone levels in hypogonadal men.

 COMPLEMENTARY SUPPLEMENTS

Vitamin D

Vitamin D is known to play a role in essential physiological processes, including hormone production, and a deficiency of vitamin D has been associated with low testosterone levels. The research suggests that supplementing with vitamin D may be beneficial for individuals with vitamin D deficiency to help normalize testosterone levels

1. Association between Vitamin D and Serum Testosterone Levels in Men (Clinical Endocrinology, 2010):

This study, which investigated male hormones, found a positive correlation between vitamin D levels and total testosterone levels. In sum, men with higher vitamin D levels tended to have higher testosterone levels.

2. Effect of Vitamin D Supplementation on Testosterone Levels in Men (Hormone and Metabolic Research, 2011):

In this randomized controlled trial, men with insufficient vitamin D levels were given vitamin D supplements for one year. The study found that vitamin D supplementation resulted in a significant increase in total testosterone levels.

3. Effect of Vitamin D Supplementation on Testosterone Levels in Men (Experimental and Clinical Endocrinology & Diabetes, 2019):

This is another study, published eight years later, in which men with vitamin D deficiency were given vitamin D supplements for one year. The findings indicated that vitamin D supplementation was associated with a significant increase in total testosterone levels.

4. The Effect of Vitamin D Supplementation on Testosterone Levels in Men (The Aging Male, 2017):

The impact of vitamin D supplementation on testosterone levels was evaluated in middle-aged and elderly men with vitamin D deficiency. The results showed that vitamin D supplementation led to a significant increase in total testosterone levels.

5. Serum Vitamin D is Positively Associated with Testosterone Levels in Korean Men (Endocrine Journal, 2012):

Research investigating the relationship between vitamin D levels and total testosterone levels in Korean men reported a positive, beneficial association.

It’s important to note that vitamin D supplementation may have a more significant impact on individuals with vitamin D deficiency or insufficiency.

Trace Minerals

When supplementing minerals, you’ll want a mineral formula that includes boron, which supports both physiology and Testosterone. Some studies have suggested that boron supplementation can increase testosterone levels.

1. Effects of Boron Supplementation on the Hormonal Profile and Performance in College Football Players (Journal of Exercise Physiology Online, 2006):

The effect of boron supplementation on Testosterone was evaluated in college football players. The results indicated that boron supplementation led to a significant increase in serum testosterone levels.

2. The Effect of Boron Supplementation on Its Urinary Excretion and Selected Cardiovascular Risk Factors in Healthy Male Subjects (Biological Trace Element Research, 2007):

This study investigated the impact of boron supplementation on urinary boron excretion and on selected cardiovascular risk factors. The findings indicate that boron supplementation is associated with an increase in serum testosterone levels.

BOTANICALS WITH MIXED RESULTS

Fadogia Agrestis

Fadogia agrestis is an herb native to Africa, with traditional medicinal applications that include boosting testosterone levels. However, research on the effects of Fadogia agrestis on testosterone levels to date has been limited to chemical assays and animal studies.

1. Effects of Fadogia agrestis Extract on Serum Testosterone and Adaptations to Resistance Training in Male Rats (Journal of the International Society of Sports Nutrition, 2005):

This study investigated the effects of Fadogia agrestis extract on serum testosterone levels and muscle adaptations in male rats undergoing resistance training. The results indicated that Fadogia agrestis extract supplementation led to a significant increase in serum testosterone levels compared to the control group of animals.

2. Effect of Oral Administration of Aqueous Extract of Fadogia agrestis Stem on Some Testicular Function Indices of Male Wistar Rats (Journal of Ethnopharmacology, 2013):

This study examined the impact of oral administration of Fadogia agrestis extract on testicular function in male rats. The findings suggested that Fadogia agrestis extract may have a positive influence on some testicular function indices, including testosterone levels.

Fenugreek

Fenugreek is an herb that has been studied for its potential to support healthy testosterone levels and improve libido and sexual function. There have been several studies investigating the potential effects of fenugreek supplementation on testosterone levels and related parameters. While some studies have suggested a positive influence, it’s important to note that the results have been mixed, and the mechanisms by which fenugreek may impact Testosterone are not fully understood. Here are a few studies that have explored the relationship between fenugreek and Testosterone:

1. Effect of Furosap, a Standardized Fenugreek Seed Extract, on Serum Testosterone Levels in Healthy Men (Phytotherapy Research, 2017):

This study examined the effects of a fenugreek seed extract (Furosap) on testosterone levels in healthy men. The researchers found that the group receiving Furosap experienced a significant increase in total and free testosterone levels compared to the placebo group.

2. Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum, Furosap®) in Enhancing Testosterone Levels in Healthy Men (Journal of Sport and Health Science, 2016):

Researchers evaluated the effects of Furosap, a fenugreek seed extract, on testosterone levels in healthy men. The results indicated a significant increase in testosterone levels in the Furosap group compared to the placebo group.

3. Effects of a Purported Aromatase and 5α-Reductase Inhibitor on Hormone Profiles in College-Age Men (International Journal of Sport Nutrition and Exercise Metabolism, 2010):

This study examined the effects of a fenugreek supplement on hormone profiles in college-age men. The results showed that the fenugreek supplement did not significantly affect testosterone levels but had some impact on other hormones.

Tribulus

Tribulus terrestris is an herb that has been traditionally used in various cultures as an aphrodisiac and to enhance athletic performance. It has also been investigated for its potential effects on testosterone levels. However, the results of studies on the impact of Tribulus terrestris on Testosterone have been mixed, and the mechanisms by which it may influence Testosterone are not well-established.

1. The Effect of Five Weeks of Tribulus terrestris Supplementation on Muscle Strength and Body Composition During Preseason Training in Elite Rugby League Players (Journal of Strength and Conditioning Research, 2007):

This study examined the effects of Tribulus terrestris supplementation on muscle strength and body composition in elite rugby league players. While the study did not find any significant changes in testosterone levels, it reported improvements in muscle endurance and overall athletic performance.

2. The Aphrodisiac Herb Tribulus terrestris Does Not Influence Androgen Production in Young Men (Journal of Ethnopharmacology, 2005):

This study investigated the effects of Tribulus terrestris supplementation on hormone production in young men. The results showed that Tribulus terrestris did not significantly affect testosterone levels or other androgen hormones.

3. Effects of a Herbal Supplement Containing Tribulus terrestris on Testosterone, Epitestosterone, and Performance in Resistance-Trained Men (International Journal of Sport Nutrition and Exercise Metabolism, 2007):

This study investigated the effects of a herbal supplement containing Tribulus terrestris on Testosterone and epitestosterone levels in resistance-trained men. The results did not show significant changes in testosterone levels.

4. The Effects of Tribulus terrestris on Body Composition and Exercise Performance in Resistance-Trained Males (International Journal of Sport Nutrition and Exercise Metabolism, 2016):

This study examined the impact of Tribulus terrestris supplementation on body composition and exercise performance in resistance-trained males. It found no significant changes in testosterone levels but reported improvements in body composition and some aspects of exercise performance.

To purchase SupporT, please visit AFFIRM Science.

To learn more about Dr. Judson Brandeis, please visit BrandeisMD.com.